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![]() Presented at the 2022 Tandem Meeting Salt Lake City, Utah April 23-26, 2022. Post-transplant cyclophosphamide versus tacrolimus and methotrexate to prevent graft-versus-host-disease in recipients of matched donor transplantation: comparison of sequential cohorts in a prospective trial. Iptacopan at a chronic dose of 200 mg twice daily was well tolerated without any major drug-related safety findings and shows lactate dehydrogenase reduction and haemoglobin normalisation in most patients with paroxysmal nocturnal haemoglobinuria at week 13 and beyond, even in monotherapy. ![]() All you’re doing is spreading out your regimen, but the impact is tremendous. This idea of giving a longer regimen or giving a regimen over a 3-week period allows a reduction in mortality and delivery of this particular treatment to all the patients. For us, this fractionated (see note on the side) busulfan regimen along with post-transplant cyclophosphamide is the go-to regimen. Paroxysmal-nocturnal hemoglobinuria with onset in childhood and adolescence. Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired disorder of the hematopoietic stem cell that makes blood cells more sensitive to the action of complement. Impaired hematopoiesis in paroxysmal nocturnal hemoglobinuria/aplastic anemia is not associated with a selective proliferative defect in the glycosylphosphatidylinositol-anchored protein-deficient clone. Patients with PNH have been transplanted successfully but a considerable cost in the continued use of high dose eculizumab. In our center, we are seeing these results first. Maciejewski JP, Sloand EM, Sato T, Anderson S, Young NS. The International Paroxysmal Nocturnal Hemoglobinuria (PNH) Registry (NCT01374360) was initiated to optimize patient management by collecting data regarding disease burden, progression, and clinical outcomes. PNH results in the death of approximately 50 of affected individuals due to thrombotic complications and, until recently, had no specific therapy. We believe that in many centers, post-transplant cyclophosphamide may become the standard for GVHD prophylaxis. Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, chronic, debilitating disorder that most frequently presents in early adulthood and usually continuous throughout the life of the patient. MD Anderson Cancer Center, Huston, Texas, USA. There are other studies which are randomizing the use of post-transplant cyclophosphamide vs tacrolimus plus methotrexate, and they will add to the literature. Paroxysmal nocturnal hemoglobinuria: A multicenter study from Saudi Arabia. Additionally, he spoke about implementation of the regimen and its potential as standard therapy going forward. Ph.D UMass Memorial Medical Center Bruce Camitta, M.I Midwest Children's Cancer Center Richard Champlin, M.D. Results of the trial (NCT02250937) showed that the regimen helped to reduce severe GVHD and nonrelapse mortality vs standard methotrexate/tacrolimus. Popat, MD, professor and deputy chair ad interim in the Department of Stem Cell Transplantation, Division of Cancer Medicine, at the University of Texas MD Anderson Cancer Center in Houston, during the 2022 Tandem Meeting about the impact of results regarding post-transplant cyclophosphamide following myeloablative busulfan and matched donor hematopoietic cell transplantation to prevent graft-vs-host disease (GVHD) for patients with acute myeloid leukemia and myelodysplastic syndrome. Compare with other Hematology Specialists. Perform age-appropriate screening as indicated.CancerNetwork® spoke with Uday R. Pancreatic Cancer Pancytopenia Paroxysmal Nocturnal Hemoglobinuria Peripheral T-Cell Lymphoma. Iptacopan monotherapy in patients with paroxysmal nocturnal hemoglobinuria: a 2-cohort open-label proof-ofconcept study. Other laboratory tests as indicated (eg, antibody testing to evaluate for heparin-induced thrombocytopenia if applicable)Įxtensive screening for malignancy not recommended. This should include obstetric history in women because recurrent second- or third-trimester fetal loss may suggest antiphospholipid antibody syndrome or hereditary thrombophiliaĭetailed family history with inquiry regarding female family members who have taken oral contraceptives or suffered any venous thrombotic events during pregnancyĬBC and peripheral smear to evaluate for underlying disease (eg, myeloproliferative disorder such as essential thrombocythemia, polycythemia vera or microangiopathic hemolysis) History and examination to identify acquired risk factors (see above). Evaluation of a Patient After a VTE: Routine Evaluation Contact to configure the session end time on user inactivity. The default inactivity period when the session is considered to end is 30 minutes and the session end time is configurable. Inactivity time is the time window when the user is not performing any event or activity. Session duration is determined as the difference between the session start time and session end time. All the events or activities performed between the session start and end time are part of the session. If the user is inactive for longer than the defined inactivity period (default 30 mins)Įvery session has a session start time and a session end time. If the current session is active and the user has entered the session from another traffic source. Session end is defined as the following scenarios: The very first event or activity performed by the user on a device starts the session. User activity or events that are part of the server, will not be part of any session. Sessions are primarily tracked using events/activities performed by the user on the device. Average Duration between two user sessionsĪ session is a group of interactions performed by the user on your website or app in a defined time period.Count of Sessions with specific Event (Example Conversion).Number of Events in Session, Number of Unique Events in Session, Events per Session, and Unique Events per session.Total number of Sessions and Number of Sessions Per User.Session Duration & Average Session Duration. ![]() ![]() You can use Session Analysis to answer the following questions: Sessions provide the quality of the user sessions on your app and web. Session analysis is used for product and design improvements. The Session Analysis of MoEngage Analytics helps you understand the user interaction with your web and mobile apps. Screen+, a similar desktop environment mode found on the LG Velvet and V60 phones.Easy Projection, a similar desktop mode found on the Huawei Mate 10, Mate 20 and Huawei Mate 30 phones.Ready For, a feature of some high-end Motorola phones that includes a desktop mode as well as TV, Video Chat and Game modes.Webtop, a similar feature of the Motorola Atrix series from the early 2010s, which required specialized hardware.They function as an external monitor, keyboard and trackpad while supplying power to the phone. In 2020, wireless Dex was introduced, enabling Note 9 and newer phones to use Miracast to project the desktop experience to a PC previously connected via USB or a wireless monitor/TV.Ī few manufacturers (NexDock, HP, UPerfect and others) have created “LapDocks”, which are essentially laptop shells with no CPU, RAM, Disk or OS. In October 2019 Samsung announced that Linux on DeX will not be available for Android 10 and warned users that after upgrade to Android 10 they will not be able to downgrade back, permanently losing the ability to use full Linux applications. Samsung DeX devices can be managed by Samsung Knox (3.3 and higher) to allow or restrict access using the Knox platform for added control and security. As of April 2022, MacOS and Windows 7 are no longer supported. Users are able to connect to their mobile devices with a USB Cable. The DeX Desktop can also be accessed with a downloadable app for Windows and MacOS or through third party accessories. ![]() Samsung also announced "Linux on Galaxy" (since renamed to "Linux on DeX") which allows use of a compatible Linux distribution rather than the default Android OS giving full personal computer capabilities. ĭeX has also been used in the public safety setting to replace in-vehicle laptops. Since 2019, with the Note 10 and Galaxy Fold, DeX can now be launched via a direct cable connection to a physical computer using the existing provided charging cable or any similar off-the-shelf USB-C cable with data transfer, eliminating the need for any proprietary docking accessories. This design enabled the cell phone to lay flat and function as a touchpad or even continue being used as a phone in its usual fashion whilst being connected to a display and with DeX operating. This provided a USB-C port, HDMI and two USB ports. Īlso in 2018, Samsung released the DeX PAD. This design enabled the cell phone to lie flat and function as a touchpad or even continue being used as a phone in its usual fashion whilst being connected to a display and with DeX operating. In August 2018 with the launch of the Note 9, Samsung introduced the DeX HDMI adapter (USB-C to female HDMI), DeX cable (USB-C to male HDMI) and DeX multiport adapter, which whilst still proprietary and containing active electronics, eliminated the need for the previous docking accessories. This provided a USB-C port, Ethernet, HDMI 2.0 output and two USB 2.0 ports. In 2017, the original version of DeX was released, which required the use of a proprietary docking accessory called the DeX Station. The feature is also available on many Galaxy Tab S models, from Galaxy Tab S4 onwards. ![]() The Galaxy A90 5G is the first Galaxy A phone with DeX support. Samsung first included the DeX feature on the Galaxy S8, and has continued to support the feature on most of their high-end smartphones, including the Galaxy S, Note and Z Fold lines. The name " DeX" is a contraction of " Desktop eXperience".įor technical specifications, Samsung DeX requires hardware such as USB 3.1 transfer specification, USB-C port with DisplayPort Alternate Mode support to be present on a mobile device. Samsung DeX (stylized as SΛMSUNG DeX) is a feature included on some high-end Samsung handheld devices that enables users to extend their device into a desktop-like experience by connecting a keyboard, mouse, and monitor. ![]() DeX Station when opened, showing the USB-C docking. ![]() Monitor is displaying the PowerPoint and Word Android applications. Feature that enables users to extend their phone to a desktop-like experience Logo of Samsung DeX The Samsung Galaxy S8 plugged into the DeX docking station. In fact, the durability and blunt changes are just frustrating. I still don't really like the state of armor, and the recent changes don't really do anything to alleviate that. I pretty much have the same gripes about armor/ammo as I did the last time I made one of these threads. I didn't want to clump my opinions with objective facts in the original post so I'm posting my opinions on armor in a comment so it can be individually up/downvoted. Learn random little things to improve your play, or something.Ī big thanks to everyone for hanging out with me in my stream last night, I stream every evening around 6pm to 4am PST now! Once I get the material information I can say exactly which ammo can and cannot penetrate body parts, as well as calculate their penetration and total fragmentation chance, so that'll be neat.Ĭome check out my stream, I have no idea what I'm doing streaming and can't promise it'll be fun, but come hang out, ask me questions, watch me metastomp people and test things. Fragmentation increases the damage of the hit by 50%. With armor, the armor has to be penetrated first for a bullet to fragment. However it works a little weird, for a bullet to fragment it has to penetrate first, which means the high flesh damage/high frag chance bullets like 5.56 HP can't actually fragment at all because they can't penetrate a body part in the first place. Helmets and Fshields vary from 5-10%, but a lot of them have 0% which is probably an oversight.įragmentation chance applies to getting hit by bullets now, it previously only applied to bullets penetrating objects. This means hollow points and buckshot do a lot of damage through armor regardless of what armor people are wearing, but AP rounds do very little. How blunt damage works is it's just a multiplies the damage of the bullet by a % and then does that damage to the body part hit when armor stops the bullet. This is a nerf to armor protection, with people no longer having 100% condition armor most of the time, the chances of lower end ammo penetrating goes up in general.īlunt damage was massively increased across the board. This massively reduces the lifespan of armor, and as a result also massively reduces the consistency of penetration chances as almost nobody is going to be using 100% condition armor anymore. This means that a 60/60 Fort is no longer considered at 100% condition, but rather 60/80 or 75% condition. The durability % that is used to calculate the penetration chance is no longer (current durability/current maximum durability) and is now (current durability/ original maximum durability). This impacts more durable materials quite a bit, and all armor takes more durability damage in general. It was increased by a flat 10% across the board, except for Glass (faceshields). I do this for transparency: the more everyone knows about the inner workings of the game, the better feedback people can give on balance and mechanics.Īrmor materials' destructibility was changed, this is a multiplier to how much durability damage armor takes. I made the tables using the internal game damage and penetration calculation. How did you make these tables, or know all this? - I decompiled the game and took a look at how everything works. ![]() Updated website containing detailed information on armor mechanics: I'll have the new tables up tomorrow or Sunday. I also have to figure out a new format to show lower durabilities. Tables aren't updated yet, there were some changes to armor material destructibility, so armor now takes 10-33% more damage depending on the armor material. Moderator decisions are final, please respect the moderator team and their actions. Make sure to follow the guidelines outlined in the Reddiquette for a more pleasant experience. ![]() Recent News Official LinksĪs well as the above rules, the Reddit Content Policy is in place as well - please familiarize yourself with this. Please make sure to follow the rules noted below in the side bar. This is an unofficial, community-run subreddit. Escape from Tarkov is a hardcore and realistic online first-person action RPG/Simulator with MMO features and a story-driven walkthrough currently in development by Battlestate Games. ![]() As I’m about to fall asleep, goodnight to you my dear! Haven’t talked to you in a few days and I almost died without texting you.I just want to tell you how much I miss your arms around me when I am not in them! My heart skips a beat with every text message or phone call from you. The thought of you makes me smile and reminisce on all the happy times we’ve shared together. I wake up each day thinking about you even more than the day before. I hope your morning has started out well and that all of your dreams come true. Good morning, beautiful! Every morning is better with you in it, it is only a few hours until I see your gorgeous face.You can’t see it, but I am sneaking a kiss to you right now in the form of a good-morning message. I hope you have an amazing day and that it’s filled with great things. Even though you’re far away, I still feel you near me. I was thinking of you early this morning.In my dreams every night I just think of you, imagine how we will be together forever. ![]()
![]() Luckily, most of our top picks come in a variety of sizes, starting at just three and a half feet tall. Height: When it comes to a fake Christmas tree, the bigger, the better is often a good mantra to follow, but giant options won't always fit. ![]() Here are a few things to consider before making your purchase. It's our personal opinion that buying an artificial Christmas tree is easier and more cost-effective than the real thing, so if you're looking to save, you've come to the right place. Ahead, you'll find more than a few suitable and stylish artificial Christmas trees that will infuse your space with festive flair. So if you're in the market for a fresh-looking find you can enlist year after year, you've come to the right place. Not only are they more sustainable, but they usually come predecorated or at least prelit. Though few things beat the scent of a fresh evergreen, we can hardly stomach tossing the sweet-scented tree at the end of the year, and that's where these faux alternatives come in. In fact, plenty of our favorite finds may even find their way into House Beautiful editors' homes. We searched the internet for longer than we'd like to admit in search of the top fake Christmas tree on the market, and after carefully choosing 13 worthy options, we're pretty proud of ourselves. ![]() That's why we're snagging the best artificial Christmas trees this year. There's nothing more tiring or messy than lugging a nine-foot Douglas fir into the house on a freezing winter day. ![]() Keisuke was surprised by Nemu’s behavior but he wants to protect Kanae and decides for the sake of escaping, he will violate the others. Nemu takes advantage, forcing the protagonist to submit to her as she brings her lips up to his ear: “This is a contract kiss.” However, Nemu could see right through him and knew. That was his secret, his urge to assault and humiliate girls. However, Keisuke seemed to be getting aroused by Miyako’s appearance. ![]() 22, 2022, download Euphoria hentai in high quality Euphoria at Watch Hentai. With eyes wide open in fear, she pisses and shits herself. Stream Euphoria episode 5 english subbed posted Nov. Her screaming begins in tandem with the electrical current. Keisuke Takatou wakes up in a featureless white room, unaware of how and when he arrived. ![]() Suddenly the lights go out, the girls scream, then lights return reilluminating the room to show Miyako bound to a grotesque torture device. “Anyone who quits the game will die.” Read reviews on the anime Euphoria on MyAnimeList, the internets largest anime database. With an assigned act, he must “use the key”.Īfter hearing the unreasonable and immoral requirements to win, Miyako gets pissed and snaps on the mysterious voice. In order to escape the room, Keisuke is the “unlocker” and one heroine the “keyhole”. While still confused about their unusual situation, a mysterious voice suddenly speaks to them: “A game has now started.” Six people find themselves trapped in a mysterious futuristic complex, forced to dance to the tune of a sadistic computer game, where failure to follow the game rules results in death.Ĭharacters include our protanist, Takato Keisuke, his childhood friend Hokari Kanae, classmate Ando Miyako, underclassmate Mikaba Rika, English teacher Aoi Natsuki, same year Byakuya Rinne, and classmate Manaka Nemu. Seek prompt medical care if you've been swarmed by bees and have multiple stings. If you were prescribed an emergency epinephrine autoinjector (EpiPen, Auvi-Q, others), use it right away as your doctor directed. In more-severe cases, you'll need immediate care.Ĭall 911 or other emergency services if you're having a serious reaction to a bee sting that suggests anaphylaxis, even if it's just one or two signs or symptoms. In most cases, bee stings don't require a visit to your doctor. You've had other symptoms of an allergic response to a bee sting.Bee sting symptoms don't go away within a few days.Make an appointment to see your doctor if: Talk to your doctor or an allergy specialist about prevention measures such as immunotherapy ("allergy shots") to avoid a similar reaction in case you get stung again. People who have a severe allergic reaction to a bee sting have a 30 to 60 percent chance of anaphylaxis the next time they're stung. Skin reactions, including hives and itching and flushed or pale skin.Signs and symptoms of anaphylaxis include: A small percentage of people who are stung by a bee or other insect quickly develop anaphylaxis. This will worsen itching and swelling and increase your risk of infection.Ī severe allergic reaction (anaphylaxis) to bee stings is potentially life-threatening and requires emergency treatment. If itching or swelling is bothersome, take an oral antihistamine that contains diphenhydramine (Benadryl) or chlorpheniramine (Chlor-Trimeton).Apply hydrocortisone cream or calamine lotion to ease redness, itching or swelling.If the sting is on an arm or leg, elevate it.You might try ibuprofen (Motrin IB, Children's Motrin, others) to help ease discomfort. Take an over-the-counter pain reliever as needed.Wash the affected area with soap and water.The following steps may help ease the swelling and itching often associated with large local reactions: If this happens to you, talk to your doctor about treatment and prevention, especially if the reaction becomes more severe each time. But some people develop similar moderate reactions each time they're stung. Having a moderate reaction doesn't mean you'll have a severe allergic reaction the next time you're stung. Moderate reactions tend to resolve over five to 10 days. Swelling at the site of the sting that gradually enlarges over the next day or two.Some people who get stung by a bee or other insect have a bit stronger reaction, with signs and symptoms such as: Baking soda: A baking soda paste (1/4 cup baking soda mixed with 1 or 2 tablespoons of water) might help neutralize the sting and reduce inflammation. Wash the sting area with soap and water. Apple cider vinegar: The theory is that vinegar neutralizes bee sting venom and helps reduce swelling.Try soaking a washcloth in vinegar and placing it on the sting for 15 minutes. ![]() Get the stinger out any way you can, such as with your fingernails or a tweezer. Remove the stinger as soon as you can, as it takes only seconds for all of the venom to enter your body.In most people, the swelling and pain go away within a few hours. Instant, sharp burning pain at the sting site. Good search words to use are: "nes hardware," "SNES hardware," "super nintendo," or "video game systems," along with the words "sale" or "sell." We suggest you research the company to ensure they are reputable before making a purchase. One of the fastest-selling consoles of all time. You may also want to try searching the Internet for companies that may have the product you are looking for. Since it hit the market in 2017, the Nintendo Switch has been a huge hit with gamers young and old. Cartridge Games: Original box & manuals are not required but will improve your trade in value if in. From the classic NES, SNES and Nintendo 64 to the latest Switch and 3DS handheld consoles, find yourself a second-hand Nintendo console. To receive full trade-in value, Games & Consoles must include all components that were included when purchased as new, such as a genuine controller, power & AV cable. Online auction sites are often a good source of hard-to-find or discontinued products. Trade-in value can vary depending upon condition and current value of product. Here's what you should expect to get for it: Nintendo Switch 250 - 300 Switch Lite 150 - 200 Switch OLED 300 - 350 Some of the best places to sell a used Nintendo. As such, you can expect to sell your used Switch for a decent amount if it's in good condition. Remember, cleaning before use is highly recommended. The Nintendo Switch is a very hot commodity, even a used one. You can often find great deals and games that can be difficult to find. Order online for delivery or in-store pick-up and save with our buy now, pay later option. Garage Sales, Flea Markets, or Classified Ads Shop new and pre-owned Nintendo Switch games at GameStop. Pawn Shopsīelieve it or not, pawn shops are an excellent place to find older products. Many online retailers specialize in stocking older and used products. IMPORTANT: When Trading-in any console it must be fully working with the manufacturers guarantee security seal(s) intact. Although many parts and accessories for our older systems are no longer available, you may find what you need in the My Nintendo Store. We sell accessories, replacement parts, and a selection of Authentic Nintendo Refurbished Products on (U.S. We have collected a list of sources you can use to help locate refurbished, older, and used Nintendo products. Prices for used Nintendo Switches with neon red/blue joy-cons and Nintendo Switch Lites with gray joy-cons in good to very good condition. |
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